Conduction-system pacing · longitudinal surveillance

Capture Threshold Surveillance Separating exercise-state variance from chronic drift — n-of-1 monitoring framework

Azure XT DR · dual chamber
3830 SelectSecure — LBBAP
5076 — RA
phase: —

Signal vs. noise — raw and state-adjusted threshold

amplitude @ fixed PW
raw measured state-adjusted exercise-state record ±2σ / ±3σ baseline band

Drift detector — tabular CUSUM on adjusted series

k=0.5σ · h=5σ
Upward accumulation crossing the decision interval = sustained chronic rise that is not explained by exercise state. Downward channel tracks threshold improvement.

Corroborating channels

impedance · sensing · safety margin
impedance (Ω) R-wave (mV) safety margin (×)

Surveillance channels

A–E

Estimated exercise-state offsets

removed from adjusted series · chronic phase
Staten (chronic)Mean thresholdOffset vs referenceAdjustment

Add measurement

Manual rested anchors are the reference series the drift detector trusts most. Enter paced QRSd / Stim-LVAT whenever a 12-lead is captured — the device's automatic capture management cannot see loss of conduction-system capture, only myocardial threshold.

Model controls

n-of-1
advanced SPC parameters

Records

0
dated+phasechamberstatethr (V)adj (V)zimp ΩR mVQRSd

Methods — how the two are told apart

read me

1 · Quantify the state component, then remove it

The measured threshold is treated as baseline + chronic_trend + state_effect + noise. Each record is tagged by exercise state. On chronic-phase data the mean threshold of every non-reference state is differenced against the rested reference to estimate a state offset; the adjusted series subtracts each record's offset. Strata with fewer than two chronic records are left unadjusted and flagged low-confidence rather than fit on one point.

2 · Establish a baseline only after maturation

The phase clock runs off implant date: <42 d acute, 42–90 d maturing, >90 d chronic. The early peak-and-settle (your 0.50 → 0.875 → plateau) is maturation, not drift, and is excluded from baseline statistics. Mean and SD come from the first N chronic adjusted anchors.

3 · Detect drift on the adjusted series

A standardized tabular CUSUM (k=0.5σ slack, h=5σ decision interval) accumulates small sustained departures — the right tool for slow drift that never trips a single-point limit. An EWMA (λ=0.2) corroborates. Because state variance has been removed first, an exercise-day spike no longer feeds the accumulator.

4 · Triangulate mechanism before acting

Rising threshold with rising impedance points to conductor/insulation change or microdislodgement; rising threshold with stable impedance points to interface fibrosis or a capture transition. The decisive LBBAP-specific check is conduction-system capture: a lengthening paced QRSd or Stim-LVAT signals loss of the conduction component even when the myocardial threshold the device reports is flat. That channel is manual because no automatic algorithm computes it.

Caveats

An n-of-1 framework; offsets are descriptive, not inferential, at small n. Automatic capture management reports myocardial capture — confirm conduction capture on 12-lead. HyperkAlemia, antiarrhythmic changes and electrolyte shifts are acute threshold modifiers that should be logged in notes and read as state, not drift.